Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein
F Dong, M Feldmesser, A Casadevall… - Journal of Biological …, 1998 - ASBMB
We have cloned cDNA that encodes six novel A kinase anchor proteins (collectively named
AKAP-KL). AKAP-KL diversity is generated by alternative mRNA splicing and utilization of
two translation initiation codons. AKAP-KL polypeptides are evident in lung, kidney, and
cerebellum, but are absent from many tissues. Different isoforms predominate in different
tissues. Thus, AKAP-KL expression is differentially regulated in vivo. All AKAP-KL isoforms
contain a 20-residue domain that avidly binds (K d∼ 10 nm) regulatory subunits (RII) of …
AKAP-KL). AKAP-KL diversity is generated by alternative mRNA splicing and utilization of
two translation initiation codons. AKAP-KL polypeptides are evident in lung, kidney, and
cerebellum, but are absent from many tissues. Different isoforms predominate in different
tissues. Thus, AKAP-KL expression is differentially regulated in vivo. All AKAP-KL isoforms
contain a 20-residue domain that avidly binds (K d∼ 10 nm) regulatory subunits (RII) of …
