Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
Previous studies have shown that the rate of fatty acid synthesis is elevated by more than 20-
fold in livers of transgenic mice that express truncated nuclear forms of sterol regulatory
element-binding proteins (SREBPs). This was explained in part by an increase in the levels
of mRNA for the two major enzymes of fatty acid synthesis, acetyl-CoA carboxylase and fatty
acid synthase, whose transcription is stimulated by SREBPs. Fatty acid synthesis also
requires a source of acetyl-CoA and NADPH. In the current studies we show that the levels …
fold in livers of transgenic mice that express truncated nuclear forms of sterol regulatory
element-binding proteins (SREBPs). This was explained in part by an increase in the levels
of mRNA for the two major enzymes of fatty acid synthesis, acetyl-CoA carboxylase and fatty
acid synthase, whose transcription is stimulated by SREBPs. Fatty acid synthesis also
requires a source of acetyl-CoA and NADPH. In the current studies we show that the levels …