[HTML][HTML] p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts
Vascular EndothelialGrowth Factor (VEGF) is a potent mitogen for vascular endothelial cells
that has been implicated in tumor neovascularization. We show that, in hamster fibroblasts
(CCL39 cells), VEGF mRNAs are expressed at low levels in serum-deprived or
exponentially growing cells, whereas it is rapidly induced after stimulation of quiescent cells
with serum. CCL39 derivatives, transformed with Polyoma virus or with active members of
the p42/p44 mitogen-activated protein (MAP) kinase pathway, Gly/Val point mutant of Ras at …
that has been implicated in tumor neovascularization. We show that, in hamster fibroblasts
(CCL39 cells), VEGF mRNAs are expressed at low levels in serum-deprived or
exponentially growing cells, whereas it is rapidly induced after stimulation of quiescent cells
with serum. CCL39 derivatives, transformed with Polyoma virus or with active members of
the p42/p44 mitogen-activated protein (MAP) kinase pathway, Gly/Val point mutant of Ras at …