How do cytotoxic lymphocytes kill their targets?
S Shresta, CTN Pham, DA Thomas, TA Graubert… - Current opinion in …, 1998 - Elsevier
CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend
primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas
and other mechanisms to induce cell death. The molecular mechanisms used by these
pathways to induce target cell apoptosis may converge on common death substrates.
primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas
and other mechanisms to induce cell death. The molecular mechanisms used by these
pathways to induce target cell apoptosis may converge on common death substrates.
CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.
Elsevier