Cbl: many adaptations to regulate protein tyrosine kinases
CBF Thien, WY Langdon - Nature reviews Molecular cell biology, 2001 - nature.com
CBF Thien, WY Langdon
Nature reviews Molecular cell biology, 2001•nature.comResponses to extracellular stimuli are often transduced from cell-surface receptors to protein
tyrosine kinases which, when activated, initiate the formation of protein complexes that
transmit signals throughout the cell. A prominent component of these complexes is the
product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine
kinases and regulates their signalling. How, then, does this multidomain protein shape the
responses generated by these signalling complexes?
tyrosine kinases which, when activated, initiate the formation of protein complexes that
transmit signals throughout the cell. A prominent component of these complexes is the
product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine
kinases and regulates their signalling. How, then, does this multidomain protein shape the
responses generated by these signalling complexes?
Abstract
Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?
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