Metabolism of cholesteryl ester in monolayers of bovine adrenal cortical cells. Effect of an inhibitor of acyl-CoA: cholesterol acyltransferase
Z Jamal, RA Suffolk, GS Boyd, KE Suckling - Biochimica et Biophysica Acta …, 1985 - Elsevier
The effect of Sandoz compound 58-035 on cholesterol metabolism in monolayers of bovine
adrenal cortical cells was studied. 58-035 did not inhibit cholesterol ester hydrolase,
cholesterol side-chain cleavage, cholesterol synthesis from acetate, or cortisol synthesis in
cells stimulated with ACTH or in unstimulated cells. It was, however, an effective inhibitor of
formation of cholesteryl ester. The rate of formation of cholesteryl ester in the cells was
increased by additional cholesterol derived from mevalonic acid or from the hydrolysis of …
adrenal cortical cells was studied. 58-035 did not inhibit cholesterol ester hydrolase,
cholesterol side-chain cleavage, cholesterol synthesis from acetate, or cortisol synthesis in
cells stimulated with ACTH or in unstimulated cells. It was, however, an effective inhibitor of
formation of cholesteryl ester. The rate of formation of cholesteryl ester in the cells was
increased by additional cholesterol derived from mevalonic acid or from the hydrolysis of …
