Relatively little is known regarding intracellular cholesterol trafficking pathways. To resolve
some of these potential pathways, spontaneous and protein-mediated sterol transfer was
examined between different donor-acceptor membrane pairs in vitro using L-cell fibroblast
plasma membrane (PM) and microsomal (MICRO) and mitochondrial (MITO) membranes.
Several new exciting insights were provided. First, the initial rate of spontaneous molecular
sterol transfer was more dependent on the type of acceptor than donor membrane, ie …