Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis
V Papadopoulos, H Amri, N Boujrad, C Cascio, M Culty… - Steroids, 1997 - Elsevier
Steroidogenesis begins with the metabolism of cholesterol to pregneolone by the inner
mitochondrial membrane cytochrome P450 side-chain cleavage (P450scc) enzyme. The
rate of steroid formation, however, depends on the rate of cholesterol transport from
intracellular stores to the inner mitochondrial membrane and loading of P450scc with
cholesterol. In previous in vitro studies, we demonstrated that a key element in the regulation
of cholesterol transport is the mitochondrial peripheral-type benzodiazepine receptor (PBR) …
mitochondrial membrane cytochrome P450 side-chain cleavage (P450scc) enzyme. The
rate of steroid formation, however, depends on the rate of cholesterol transport from
intracellular stores to the inner mitochondrial membrane and loading of P450scc with
cholesterol. In previous in vitro studies, we demonstrated that a key element in the regulation
of cholesterol transport is the mitochondrial peripheral-type benzodiazepine receptor (PBR) …