[HTML][HTML] The mechanism of action of steroidogenic acute regulatory protein (StAR): StAR acts on the outside of mitochondria to stimulate steroidogenesis
F Arakane, CB Kallen, H Watari, JA Foster… - Journal of Biological …, 1998 - ASBMB
Steroidogenic acute regulatory protein (StAR) plays an essential role in steroidogenesis,
facilitating delivery of cholesterol to cytochrome P450 scc on the inner mitochondrial
membrane. StAR is synthesized in the cytoplasm and is subsequently imported by
mitochondria and processed to a mature form by cleavage of the NH 2-terminal
mitochondrial targeting sequence. To explore the mechanism of StAR action, we produced 6-
histidine-tagged N-62 StAR (His-tag StAR) constructs lacking the NH 2-terminal 62 amino …
facilitating delivery of cholesterol to cytochrome P450 scc on the inner mitochondrial
membrane. StAR is synthesized in the cytoplasm and is subsequently imported by
mitochondria and processed to a mature form by cleavage of the NH 2-terminal
mitochondrial targeting sequence. To explore the mechanism of StAR action, we produced 6-
histidine-tagged N-62 StAR (His-tag StAR) constructs lacking the NH 2-terminal 62 amino …