[HTML][HTML] Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents …
I Tabas, S Marathe, GA Keesler, N Beatini… - Journal of Biological …, 1996 - ASBMB
Macrophages in atherosclerotic lesions accumulate free cholesterol (FC) as well as
cholesteryl ester and appear to have high rates of phospholipid (PL) synthesis and
increased PL mass. Previous short term (ie≤ 24 h) studies with cultured macrophages have
shown that these cells respond to FC loading by up-regulating phosphatidylcholine
biosynthesis. We propose that this response is adaptive by keeping the FC: PL ratio in the
macrophages from reaching toxic levels. We further propose that one cause of macrophage …
cholesteryl ester and appear to have high rates of phospholipid (PL) synthesis and
increased PL mass. Previous short term (ie≤ 24 h) studies with cultured macrophages have
shown that these cells respond to FC loading by up-regulating phosphatidylcholine
biosynthesis. We propose that this response is adaptive by keeping the FC: PL ratio in the
macrophages from reaching toxic levels. We further propose that one cause of macrophage …