Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABAA receptors
NJ Leidenheimer, R Chapell - Molecular brain research, 1997 - Elsevier
The effect of calcium-phospholipid-dependent protein kinase (PKC) activation on
neurosteroid modulation of the GABAA receptor was examined in Xenopus oocytes
expressing human recombinant α1β2γ2L GABAA receptors. GABA-gated chloride currents
were measured using the two-electrode voltage-clamp technique. The peak amplitude of
GABA-gated chloride currents was reduced by the PKC activator phorbol 12-myristate 13-
acetate (PMA), but not by the inactive analog phorbol 12-mono-myristate (PMM). This effect …
neurosteroid modulation of the GABAA receptor was examined in Xenopus oocytes
expressing human recombinant α1β2γ2L GABAA receptors. GABA-gated chloride currents
were measured using the two-electrode voltage-clamp technique. The peak amplitude of
GABA-gated chloride currents was reduced by the PKC activator phorbol 12-myristate 13-
acetate (PMA), but not by the inactive analog phorbol 12-mono-myristate (PMM). This effect …
