[HTML][HTML] Constitutive activation of the prolactin receptor results in the induction of growth factor-independent proliferation and constitutive activation of signaling …
RCH Lee, JA Walters, ME Reyland… - Journal of Biological …, 1999 - ASBMB
The ability to induce the oncogenic activation of the human prolactin receptor (PRLR) was
examined by deleting 178 amino acids of the extracellular ligand-binding domain.
Expression of this deletion mutant in the interleukin-3 (IL-3)-dependent murine myeloid cell
line 32Dcl3 resulted in the induction of growth factor-independent proliferation. Parental
32Dcl3 cells proliferated only in the presence of exogenous murine IL-3 (mIL-3), while
32Dcl3 cells transfected with the long form of the human PRLR were able to proliferate in …
examined by deleting 178 amino acids of the extracellular ligand-binding domain.
Expression of this deletion mutant in the interleukin-3 (IL-3)-dependent murine myeloid cell
line 32Dcl3 resulted in the induction of growth factor-independent proliferation. Parental
32Dcl3 cells proliferated only in the presence of exogenous murine IL-3 (mIL-3), while
32Dcl3 cells transfected with the long form of the human PRLR were able to proliferate in …
