The tuberoinfundibular dopaminergic (TIDA) system is known to inhibit prolactin (PRL)
secretion. In young animals this system responds to acute elevations in serum PRL by
increasing its activity. However, this responsiveness is lost in aging rats with chronically high
serum PRL levels. The purpose of this study was to induce hyperprolactinemia in rats for
extended periods of time and examine its effects on dopaminergic systems in the brain.
Hyperprolactinemia was induced by treatment with haloperidol, a dopamine receptor …