[HTML][HTML] Prolactin decreases epidermal growth factor receptor kinase activity via a phosphorylation-dependent mechanism
VJ Quijano, LG Sheffield - Journal of Biological Chemistry, 1998 - ASBMB
Previously, we have shown that prolactin inhibits epidermal growth factor (EGF)-induced
mitogenesis in mouse mammary epithelial cells without altering the response to other
growth promoting agents. This effect has been associated with reduced EGF-induced EGF
receptor (EGFR) tyrosine phosphorylation, Grb-2 association, and Ras activation. Our
current hypothesis is that prolactin induces an alteration in EGFR kinase activity via a
phosphorylation-dependent mechanism. To test this hypothesis, we treated normal murine …
mitogenesis in mouse mammary epithelial cells without altering the response to other
growth promoting agents. This effect has been associated with reduced EGF-induced EGF
receptor (EGFR) tyrosine phosphorylation, Grb-2 association, and Ras activation. Our
current hypothesis is that prolactin induces an alteration in EGFR kinase activity via a
phosphorylation-dependent mechanism. To test this hypothesis, we treated normal murine …
