Transcriptional regulation of the MHC class ib genes HLA-E, HLA-F, and HLA-G
SJP Gobin, PJ van den Elsen - Human immunology, 2000 - Elsevier
The restricted tissue expression of the MHC class Ib molecules HLA-E, HLA-F, and HLA-G
has suggested specialized functions and tight transcriptional control of their genes.
Transactivation of classical MHC class I genes is mediated by two groups of juxtaposed cis-
acting elements, which can be viewed as regulatory modules. The most upstream module
consists of the enhancer A and ISRE, and mediates constitutive and cytokine induced
expression, whereas the SXY module is important for the constitutive and CIITA-mediated …
has suggested specialized functions and tight transcriptional control of their genes.
Transactivation of classical MHC class I genes is mediated by two groups of juxtaposed cis-
acting elements, which can be viewed as regulatory modules. The most upstream module
consists of the enhancer A and ISRE, and mediates constitutive and cytokine induced
expression, whereas the SXY module is important for the constitutive and CIITA-mediated …
