Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: acohort study
A Carr, K Samaras, A Thorisdottir, GR Kaufmann… - The Lancet, 1999 - thelancet.com
A Carr, K Samaras, A Thorisdottir, GR Kaufmann, DJ Chisholm, DA Cooper
The Lancet, 1999•thelancet.comBackground The prevalence and severity of lipodystrophy syndrome with long-term therapy
for HIV-1 infection that includes a protease inhibitor is unknown. We studied the natural
course of the syndrome to develop diagnostic criteria and identifying markers that predict its
severity. Methods We assessed 113 patients who were receiving HIV-1 protease inhibitors
(mean 21 months) and 45 HIV-1-infected patients (28 with follow-up) never treated with a
protease inhibitor. Lipodystrophy was assessed by questionnaire (including patients' rating …
for HIV-1 infection that includes a protease inhibitor is unknown. We studied the natural
course of the syndrome to develop diagnostic criteria and identifying markers that predict its
severity. Methods We assessed 113 patients who were receiving HIV-1 protease inhibitors
(mean 21 months) and 45 HIV-1-infected patients (28 with follow-up) never treated with a
protease inhibitor. Lipodystrophy was assessed by questionnaire (including patients' rating …
Summary
Background
The prevalence and severity of lipodystrophy syndrome with long-term therapy for HIV-1 infection that includes a protease inhibitor is unknown. We studied the natural course of the syndrome to develop diagnostic criteria and identifying markers that predict its severity.
Methods
We assessed 113 patients who were receiving HIV-1 protease inhibitors (mean 21 months) and 45 HIV-1-infected patients (28 with follow-up) never treated with a protease inhibitor. Lipodystrophy was assessed by questionnaire (including patients' rating of severity), physical examination, and dual-energy x-ray absorptiometry. Body composition and fasting lipid and glycaemic variables were compared with data obtained 8 months previously. Oral glucose tolerance was investigated.
thelancet.com