Recently cDNA encoding the histamine H3 receptor was isolated after 15 years of
considerable research. However, several studies have proposed heterogeneity of the H3
receptor. We report here the molecular cloning and characterization of a novel type of
histamine receptor. A novel orphan G-protein-coupled receptor named GPRv53 was
obtained through a search of the human genomic DNA data base and analyzed by rapid
amplification of cDNA ends (RACE). GPRv53 possessed the features of biologic amine …