The blockade of H1 receptors attenuates the suppression of feeding and diuresis induced by inhibition of histamine catabolism
A Lecklin, L Tuomisto - Pharmacology Biochemistry and Behavior, 1998 - Elsevier
Metoprine elevates brain histamine content by blocking the conversion of histamine to
methylhistamine. It suppresses food intake, increases water intake, and induces diuresis in
rats. In the present experiment, to study which receptors were involved in these metoprine-
induced changes, H1, H2, and H3 receptor blockers were administered to metoprine (10
mg/kg IP)-treated rats. The food and water consumption and urine excretion were measured
at 10 and 24 h after the drug administration. It was found that systemic administration of the …
methylhistamine. It suppresses food intake, increases water intake, and induces diuresis in
rats. In the present experiment, to study which receptors were involved in these metoprine-
induced changes, H1, H2, and H3 receptor blockers were administered to metoprine (10
mg/kg IP)-treated rats. The food and water consumption and urine excretion were measured
at 10 and 24 h after the drug administration. It was found that systemic administration of the …