Cytotoxicity of a series of mono-and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study
RCA Onderwater, JNM Commandeur, EJ Groot… - Toxicology, 1998 - Elsevier
The cytotoxicity of a series of 12 mono-and 4 di-substituted thiourea containing compounds
in freshly isolated rat hepatocytes was investigated. It was found that thiourea toxicity, as
evidenced by an increase in LDH-leakage from the cells, was accompanied by a depletion
of intracellular glutathione (GSH). No increase in lipid peroxidation was observed with any of
the thiourea. Burimamide and thioperamide, thiourea-containing histamine receptor ligands,
were also found to deplete intracellular GSH. A clear structure-toxicity relationship was …
in freshly isolated rat hepatocytes was investigated. It was found that thiourea toxicity, as
evidenced by an increase in LDH-leakage from the cells, was accompanied by a depletion
of intracellular glutathione (GSH). No increase in lipid peroxidation was observed with any of
the thiourea. Burimamide and thioperamide, thiourea-containing histamine receptor ligands,
were also found to deplete intracellular GSH. A clear structure-toxicity relationship was …