[HTML][HTML] Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin αIIbβ3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of …
SM Schoenwaelder, Y Yuan, P Cooray… - Journal of Biological …, 1997 - ASBMB
The intracellular thiol protease calpain catalyzes the limited proteolysis of various focal
adhesion structural proteins and signaling enzymes in adherent cells. In human platelets,
calpain activation is dependent on fibrinogen binding to integrin α IIb β 3 and subsequent
platelet aggregation, suggesting a potential role for this protease in the regulation of
postaggregation responses. In this study, we have examined the effects of calpain activation
on several postaggregation events in human platelets, including the cytoskeletal attachment …
adhesion structural proteins and signaling enzymes in adherent cells. In human platelets,
calpain activation is dependent on fibrinogen binding to integrin α IIb β 3 and subsequent
platelet aggregation, suggesting a potential role for this protease in the regulation of
postaggregation responses. In this study, we have examined the effects of calpain activation
on several postaggregation events in human platelets, including the cytoskeletal attachment …
