Experimental autoimmune uveoretinitis (EAU) induced by retinal interphotoreceptor retinoid-binding protein (IRBP): differences between EAU induced by IRBP and by …
GM Fox, T Kuwabara, B Wiggert, TM Redmond… - Clinical immunology and …, 1987 - Elsevier
Rats immunized with the retinal interphotoreceptor retinoid-binding protein (IRBP) develop
an inflammatory eye disease,“experimental autoimmune uveoretinitis”(EAU). The ocular
changes which characterize the EAU induced by IRBP resemble those seen in rats which
develop EAU by immunization with another retinal protein, S-antigen (S-Ag). Yet, the two
antigens do not cross-react antigenically and the two diseases differ by several features:(1)
At low doses (≤ 4 μg/rat), IRBP was more uveitogenic in Lewis rats than was S-Ag, inducing …
an inflammatory eye disease,“experimental autoimmune uveoretinitis”(EAU). The ocular
changes which characterize the EAU induced by IRBP resemble those seen in rats which
develop EAU by immunization with another retinal protein, S-antigen (S-Ag). Yet, the two
antigens do not cross-react antigenically and the two diseases differ by several features:(1)
At low doses (≤ 4 μg/rat), IRBP was more uveitogenic in Lewis rats than was S-Ag, inducing …
