Fas ligand mediates activation-induced cell death in human T lymphocytes.
MR Alderson, TW Tough, T Davis-Smith… - The Journal of …, 1995 - rupress.org
MR Alderson, TW Tough, T Davis-Smith, S Braddy, B Falk, KA Schooley, RG Goodwin…
The Journal of experimental medicine, 1995•rupress.orgA significant proportion of previously activated human T cells undergo apoptosis when
triggered through the CD3/T cell receptor complex, a process termed activation-induced cell
death (AICD). Ligation of Fas on activated T cells by either Fas antibodies or recombinant
human Fas-ligand (Fas-L) also results in cytolysis. We demonstrate that these two pathways
of apoptosis are causally related. Stimulation of previously activated T cells resulted in the
expression of Fas-L mRNA and lysis of Fas-positive target cells. Fas-L antagonists inhibited …
triggered through the CD3/T cell receptor complex, a process termed activation-induced cell
death (AICD). Ligation of Fas on activated T cells by either Fas antibodies or recombinant
human Fas-ligand (Fas-L) also results in cytolysis. We demonstrate that these two pathways
of apoptosis are causally related. Stimulation of previously activated T cells resulted in the
expression of Fas-L mRNA and lysis of Fas-positive target cells. Fas-L antagonists inhibited …
A significant proportion of previously activated human T cells undergo apoptosis when triggered through the CD3/T cell receptor complex, a process termed activation-induced cell death (AICD). Ligation of Fas on activated T cells by either Fas antibodies or recombinant human Fas-ligand (Fas-L) also results in cytolysis. We demonstrate that these two pathways of apoptosis are causally related. Stimulation of previously activated T cells resulted in the expression of Fas-L mRNA and lysis of Fas-positive target cells. Fas-L antagonists inhibited AICD of T cell clones and staphylococcus enterotoxin B (SEB)-specific T cell lines. The data indicate AICD in previously stimulated T cells is mediated by Fas/Fas-L interactions.
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