[HTML][HTML] C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels
C Viscomi, C Altomare, A Bucchi, E Camatini… - Journal of Biological …, 2001 - ASBMB
The hyperpolarization-activated cyclic nucleotide-gated (HCN) family of" pacemaker"
channels includes 4 isoforms, the kinetics and cAMP-induced modulation of which differ
quantitatively. Because HCN isoforms are highly homologous in the central region, but
diverge more substantially in the N and C termini, we asked whether these latter regions
could contribute to the determination of channel properties. To this aim, we analyzed
activation/deactivation kinetics and the response to cAMP of heterologously expressed …
channels includes 4 isoforms, the kinetics and cAMP-induced modulation of which differ
quantitatively. Because HCN isoforms are highly homologous in the central region, but
diverge more substantially in the N and C termini, we asked whether these latter regions
could contribute to the determination of channel properties. To this aim, we analyzed
activation/deactivation kinetics and the response to cAMP of heterologously expressed …
