Tissue factor pathway inhibitor inhibits endothelial cell proliferation via association with the very low density lipoprotein receptor
TA Hembrough, JF Ruiz, AE Papathanassiu… - Journal of Biological …, 2001 - ASBMB
Tissue factor pathway inhibitor (TFPI) contains three Kunitz-type proteinase inhibitor
domains and is a potent inhibitor of tissue factor-mediated coagulation. Here, we report that
TFPI inhibits the proliferation of basic fibroblast growth factor-stimulated endothelial cells. A
truncated form of TFPI, containing only the first two Kunitz-type proteinase inhibitor domains,
has very little antiproliferative activity, suggesting that the carboxyl-terminal region of TFPI is
responsible for this activity. Binding studies revealed that full-length TFPI, but not the …
domains and is a potent inhibitor of tissue factor-mediated coagulation. Here, we report that
TFPI inhibits the proliferation of basic fibroblast growth factor-stimulated endothelial cells. A
truncated form of TFPI, containing only the first two Kunitz-type proteinase inhibitor domains,
has very little antiproliferative activity, suggesting that the carboxyl-terminal region of TFPI is
responsible for this activity. Binding studies revealed that full-length TFPI, but not the …
