Reversal of collapsing glomerulopathy in mice with the cyclin-dependent kinase inhibitor CYC202
D Gherardi, V D'Agati, THT Chu, A Barnett… - Journal of the …, 2004 - journals.lww.com
Collapsing glomerulopathy (CG) has become an important cause of end-stage renal
disease. Whether associated with HIV-1 or other potential etiologies, the pathogenesis of
CG converges to induce aberrant proliferation of renal epithelium along the entire nephron.
This raises the possibility that targeting cell-cycle progression may be an effective
therapeutic strategy for CG. Here, we ask whether the cyclin-dependent kinase (CDK)
inhibitor, CYC202 (R-roscovitine), could attenuate or reverse existing renal disease in Tg26 …
disease. Whether associated with HIV-1 or other potential etiologies, the pathogenesis of
CG converges to induce aberrant proliferation of renal epithelium along the entire nephron.
This raises the possibility that targeting cell-cycle progression may be an effective
therapeutic strategy for CG. Here, we ask whether the cyclin-dependent kinase (CDK)
inhibitor, CYC202 (R-roscovitine), could attenuate or reverse existing renal disease in Tg26 …