Renal epithelium is a previously unrecognized site of HIV-1 infection
LA Bruggeman, MD Ross, N Tanji, A Cara… - Journal of the …, 2000 - journals.lww.com
The striking emergence of an epidemic of HIV-related renal disease in patients with end-
stage renal disease provided the rationale for the exploration of whether HIV-1 directly
infects renal parenchymal cells. Renal glomerular and tubular epithelial cells contain HIV-1
mRNA and DNA, indicating infection by HIV-1. In addition, circularized viral DNA, a marker
of recent nuclear import of full-length, reverse-transcribed RNA, was detected in the
biopsies, suggesting active replication in renal tissue. Infiltrating infected leukocytes …
stage renal disease provided the rationale for the exploration of whether HIV-1 directly
infects renal parenchymal cells. Renal glomerular and tubular epithelial cells contain HIV-1
mRNA and DNA, indicating infection by HIV-1. In addition, circularized viral DNA, a marker
of recent nuclear import of full-length, reverse-transcribed RNA, was detected in the
biopsies, suggesting active replication in renal tissue. Infiltrating infected leukocytes …