Augmentation of fibroblast proliferation by bleomycin.
PL Moseley, C Hemken… - The Journal of clinical …, 1986 - Am Soc Clin Investig
PL Moseley, C Hemken, GW Hunninghake
The Journal of clinical investigation, 1986•Am Soc Clin InvestigBleomycin-induced lung disease is characterized by fibroblast proliferation and pulmonary
fibrosis. In these studies, we demonstrate that fibroblasts are relatively resistant to clinically
relevant amounts (below 10 (-4) U/ml) of bleomycin and that these levels of bleomycin
augment fibroblast proliferation in response to various fibroblast growth factors. These
observations suggest that one mechanism by which bleomycin causes pulmonary fibrosis is
augmentation of fibroblast proliferation.
fibrosis. In these studies, we demonstrate that fibroblasts are relatively resistant to clinically
relevant amounts (below 10 (-4) U/ml) of bleomycin and that these levels of bleomycin
augment fibroblast proliferation in response to various fibroblast growth factors. These
observations suggest that one mechanism by which bleomycin causes pulmonary fibrosis is
augmentation of fibroblast proliferation.
Bleomycin-induced lung disease is characterized by fibroblast proliferation and pulmonary fibrosis. In these studies, we demonstrate that fibroblasts are relatively resistant to clinically relevant amounts (below 10(-4) U/ml) of bleomycin and that these levels of bleomycin augment fibroblast proliferation in response to various fibroblast growth factors. These observations suggest that one mechanism by which bleomycin causes pulmonary fibrosis is augmentation of fibroblast proliferation.
The Journal of Clinical Investigation