Lysophosphatidic acid (LPA) is a lipid mediator with multiple biological activities that
accounts for many biological properties of serum. LPA is thought to be produced during
serum formation based on the fact that the LPA level is much higher in serum than in
plasma. In this study, to better understand the pathways of LPA synthesis in serum, we
evaluated the roles of platelets, plasma, and phospholipases by measuring LPA using a
novel enzyme-linked fluorometric assay. First, examination of platelet-depleted rats showed …