Trafficking and assembly of the cold-sensitive TRPM8 channel
I Erler, DMM Al-Ansary, U Wissenbach… - Journal of Biological …, 2006 - ASBMB
TRPM (transient receptor potential melastatin-like) channels are distinct from many other
members of the transient receptor potential family in regard to their overall size (> 1000
amino acids), the lack of N-terminal ankyrin-like repeats, and hydrophobicity predictions that
may allow for more than six transmembrane regions. Common to each TRPM member is a
prominent C-terminal coiled coil region. Here we have shown that TRPM8 channels
assemble as multimers using the putative coiled coil region within the intracellular C …
members of the transient receptor potential family in regard to their overall size (> 1000
amino acids), the lack of N-terminal ankyrin-like repeats, and hydrophobicity predictions that
may allow for more than six transmembrane regions. Common to each TRPM member is a
prominent C-terminal coiled coil region. Here we have shown that TRPM8 channels
assemble as multimers using the putative coiled coil region within the intracellular C …
