[HTML][HTML] The marrow homing efficiency of murine hematopoietic stem cells remains constant during ontogeny

SJ Szilvassy, PL Ragland, CL Miller, CJ Eaves - Experimental hematology, 2003 - Elsevier
OBJECTIVE: Several recent studies have established the potential clinical utility of
hematopoietic stem cells (HSCs) not only for marrow rescue but also for regenerating
diseased or damaged nonhematopoietic tissues. These findings have focused renewed
interest in understanding the in vivo trafficking patterns of HSCs from different sources.
Previous experiments have suggested that the half-life of HSCs in the circulation is short,
although the actual proportion that return to the bone marrow (BM) following transplantation …