Differing roles of Akt and serum-and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity
H Sakoda, Y Gotoh, H Katagiri, M Kurokawa… - Journal of Biological …, 2003 - ASBMB
Serum-and glucocorticoid-regulated kinase (SGK) is a serine kinase that has a catalytic
domain homologous to that of Akt, but lacks the pleckstrin homology domain present in Akt.
Akt reportedly plays a key role in various cellular actions, including glucose transport,
glycogen synthesis, DNA synthesis, anti-apoptotic activity, and cell proliferation. In this study,
we attempted to reveal the different roles of SGK and Akt by overexpressing active mutants
of Akt and SGK. We found that adenovirus-mediated overexpression of myristoylated (myr-) …
domain homologous to that of Akt, but lacks the pleckstrin homology domain present in Akt.
Akt reportedly plays a key role in various cellular actions, including glucose transport,
glycogen synthesis, DNA synthesis, anti-apoptotic activity, and cell proliferation. In this study,
we attempted to reveal the different roles of SGK and Akt by overexpressing active mutants
of Akt and SGK. We found that adenovirus-mediated overexpression of myristoylated (myr-) …