Source of cholesterol for the ocular lens, studied with U18666A: a cataract-producing inhibitor of lipid metabolism
RJ Cenedella - Experimental eye research, 1983 - Elsevier
Cholesterol is the major lipid component of the ocular lens. The source of lens cholesterol
during the first month of post-natal life of the rat was investigated by use of U18666A, a
potent inhibitor of cholesterol biosynthesis which can also produce cataracts. Lenses from
rats treated with U18666A at a level known to produce cataracts were of smaller size and
accumulated total sterol at about one-half the rate of untreated controls. The lens content of
phospholipid also lagged behind that of controls. Desmosterol accounted for 50–75% of the …
during the first month of post-natal life of the rat was investigated by use of U18666A, a
potent inhibitor of cholesterol biosynthesis which can also produce cataracts. Lenses from
rats treated with U18666A at a level known to produce cataracts were of smaller size and
accumulated total sterol at about one-half the rate of untreated controls. The lens content of
phospholipid also lagged behind that of controls. Desmosterol accounted for 50–75% of the …