De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome
MF McCarty - Medical hypotheses, 2005 - Elsevier
Increased free fatty acid flux, giving rise to increased de novo synthesis of diacylglycerol
(DAG) and activation of protein kinase C (PKC) in vascular endothelium, may be largely
responsible for the endotheliopathy and increased vascular risk associated with insulin
resistance syndrome. This mechanism may also mediate, in large part, the increase in
plasminogen activator inhibitor-1 (PAI-1) observed in this syndrome. PKC activation
promotes transcription of PAI-1 in endothelial cells and other tissues, apparently by boosting …
(DAG) and activation of protein kinase C (PKC) in vascular endothelium, may be largely
responsible for the endotheliopathy and increased vascular risk associated with insulin
resistance syndrome. This mechanism may also mediate, in large part, the increase in
plasminogen activator inhibitor-1 (PAI-1) observed in this syndrome. PKC activation
promotes transcription of PAI-1 in endothelial cells and other tissues, apparently by boosting …