Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection
CV Samuelsson, S Lienenklaus, PP Müller… - Biochemical and …, 2005 - Elsevier
CV Samuelsson, S Lienenklaus, PP Müller, R Zawatzky, H Hauser, S Weiss
Biochemical and biophysical research communications, 2005•ElsevierType I interferons (IFNs) have been shown to be involved in many immune defence and
inflammatory responses. We here show that IFN-β plays an absolute essential role in the
efficient induction of all type I IFNs after infection of primary embryonic as well as primary
adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with
SV40 large T antigen, IFN-α4 can be induced independently of IFN-β. However, efficient
secretion of type I IFNs even in immortalized fibroblasts is only found when the complete …
inflammatory responses. We here show that IFN-β plays an absolute essential role in the
efficient induction of all type I IFNs after infection of primary embryonic as well as primary
adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with
SV40 large T antigen, IFN-α4 can be induced independently of IFN-β. However, efficient
secretion of type I IFNs even in immortalized fibroblasts is only found when the complete …
Type I interferons (IFNs) have been shown to be involved in many immune defence and inflammatory responses. We here show that IFN-β plays an absolute essential role in the efficient induction of all type I IFNs after infection of primary embryonic as well as primary adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with SV40 large T antigen, IFN-α4 can be induced independently of IFN-β. However, efficient secretion of type I IFNs even in immortalized fibroblasts is only found when the complete signalling loop is induced by IFN-β.
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