Interferon beta increases c-Myc proteolysis in mouse monocyte/macrophage leukemia cells
X Hu, J Bies, L Wolff - Leukemia research, 2005 - Elsevier
Growth inhibitory activity of interferons (IFNs) has been attributed to several events. These
include rapid induction of cyclin-dependent kinase inhibitors, such as those in the Cip/Kip
and Ink4 families and down-regulation of c-myc mRNA and c-Myc transcriptional activity.
Here, we report an additional mechanism, involving regulation of Myc protein levels, through
which type 1 IFN may halt proliferation of cells. This was discovered using a cell line which
constitutively expresses c-myc from a retrovirus vector and which was reported to have …
include rapid induction of cyclin-dependent kinase inhibitors, such as those in the Cip/Kip
and Ink4 families and down-regulation of c-myc mRNA and c-Myc transcriptional activity.
Here, we report an additional mechanism, involving regulation of Myc protein levels, through
which type 1 IFN may halt proliferation of cells. This was discovered using a cell line which
constitutively expresses c-myc from a retrovirus vector and which was reported to have …