Angiogenesis in osteoarthritis
S Ashraf, DA Walsh - Current opinion in rheumatology, 2008 - journals.lww.com
S Ashraf, DA Walsh
Current opinion in rheumatology, 2008•journals.lww.comMolecular mechanisms and consequences of angiogenesis in osteoarthritis are slowly
being elucidated. Studies, both in humans and animal models, support the notion that
inhibiting angiogenesis will provide effective therapeutic strategies for treating osteoarthritis.
Better techniques that can more precisely visualize the vascular changes of the whole joint
can further enhance our understanding of osteoarthritis, and can provide proof of concept
and early evidence of efficacy in trials of novel therapeutic interventions.
being elucidated. Studies, both in humans and animal models, support the notion that
inhibiting angiogenesis will provide effective therapeutic strategies for treating osteoarthritis.
Better techniques that can more precisely visualize the vascular changes of the whole joint
can further enhance our understanding of osteoarthritis, and can provide proof of concept
and early evidence of efficacy in trials of novel therapeutic interventions.
Summary
Molecular mechanisms and consequences of angiogenesis in osteoarthritis are slowly being elucidated. Studies, both in humans and animal models, support the notion that inhibiting angiogenesis will provide effective therapeutic strategies for treating osteoarthritis. Better techniques that can more precisely visualize the vascular changes of the whole joint can further enhance our understanding of osteoarthritis, and can provide proof of concept and early evidence of efficacy in trials of novel therapeutic interventions.
Lippincott Williams & Wilkins