In vitro three dimensional collagen matrix models of endothelial lumen formation during vasculogenesis and angiogenesis

W Koh, AN Stratman, A Sacharidou, GE Davis - Methods in enzymology, 2008 - Elsevier
Discovery and comprehension of detailed molecular signaling pathways underlying
endothelial vascular morphogenic events including endothelial lumen formation are key
steps in understanding their roles during embryonic development, as well as during various
disease states. Studies that used in vitro three‐dimensional (3D) matrix endothelial cell
morphogenic assay models, in conjunction with in vivo studies, have been essential to
identifying molecules and explaining their related signaling pathways that regulate …