Pathogenesis of HIV-associated nephropathy
JS Leventhal, MJ Ross - Seminars in nephrology, 2008 - Elsevier
Human immunodeficiency virus–associated nephropathy (HIVAN) is a leading cause of end-
stage renal disease in the HIV-1–seropositive population. HIVAN, which is characterized by
heavy proteinuria and a rapid decline in renal function, is caused by infection and
subsequent expression of viral genes in renal epithelial cells, although the exact mechanism
of viral entry into these cells is unknown. The infected renal epithelium is a distinct
compartment that supports the evolution of viral strains that may diverge from those found in …
stage renal disease in the HIV-1–seropositive population. HIVAN, which is characterized by
heavy proteinuria and a rapid decline in renal function, is caused by infection and
subsequent expression of viral genes in renal epithelial cells, although the exact mechanism
of viral entry into these cells is unknown. The infected renal epithelium is a distinct
compartment that supports the evolution of viral strains that may diverge from those found in …