The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-κB (NF-κB)-inducing kinase to activate NF-κB: identification of a novel …
AA Habib, S Chatterjee, SK Park, RR Ratan… - Journal of Biological …, 2001 - ASBMB
The transcription factor nuclear factor-κB (NF-κB) is activated by a diverse number of stimuli
including tumor necrosis factor-α, interleukin-1, UV irradiation, viruses, as well as receptor
tyrosine kinases such as the epidermal growth factor receptor (EGFR). NF-κB activation by
the tumor necrosis factor receptor (TNFR) involves the formation of a multiprotein complex
termed a signalosome. Although previous studies have shown that the activated EGFR can
induce NF-κB, the mechanism of this activation remains unknown. In this study, we identify …
including tumor necrosis factor-α, interleukin-1, UV irradiation, viruses, as well as receptor
tyrosine kinases such as the epidermal growth factor receptor (EGFR). NF-κB activation by
the tumor necrosis factor receptor (TNFR) involves the formation of a multiprotein complex
termed a signalosome. Although previous studies have shown that the activated EGFR can
induce NF-κB, the mechanism of this activation remains unknown. In this study, we identify …
