Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
RU Janicke, ML Sprengart, MR Wati… - Journal of Biological …, 1998 - ASBMB
Interleukin 1β-converting enzyme-like proteases (caspases) are crucial components of cell
death pathways. Among the caspases identified, caspase-3 stands out because it is
commonly activated by numerous death signals and cleaves a variety of important cellular
proteins. Studies in caspase-3 knock-out mice have shown that this protease is essential for
brain development. To investigate the requirement for caspase-3 in apoptosis, we took
advantage of the MCF-7 breast carcinoma cell line, which we show here has lost caspase-3 …
death pathways. Among the caspases identified, caspase-3 stands out because it is
commonly activated by numerous death signals and cleaves a variety of important cellular
proteins. Studies in caspase-3 knock-out mice have shown that this protease is essential for
brain development. To investigate the requirement for caspase-3 in apoptosis, we took
advantage of the MCF-7 breast carcinoma cell line, which we show here has lost caspase-3 …