Cerebral damage as a consequence of glutamate-mediated excitotoxicity represents a
major consequence of stroke. However, the development of effective clinical treatments for
this potentially devastating condition has been largely unsuccessful to date, despite
promising basic research. This review will focus on the latest advances in our understanding
of the excitotoxic process including the release of glutamate as a neurotransmitter and the
potential contribution of complexins, the important role of astrocytes, including its …