Epileptic syndromes have very diverse primary causes, which may be genetic,
developmental or acquired. In rodent models, altering glutamate receptor or glutamate
transporter expression by knockout or knockdown procedures can induce or suppress
epileptic seizures. Regardless of the primary cause, synaptically released glutamate acting
on ionotropic and metabotropic receptors appears to play a major role in the initiation and
spread of seizure activity. In rodent models of acquired epilepsy and in human temporal lobe …