Increased SPARC expression promotes U87 glioblastoma invasion in vitro
WA Golembieski, S Ge, K Nelson, T Mikkelsen… - International Journal of …, 1999 - Elsevier
Our recent studies have focused on identifying invasion-promoting genes that are expressed
early in brain tumor progression. We identified and characterized SPARC (secreted protein
acidic and rich in cysteine) as a potential candidate. To determine whether increased
SPARC expression functionally promotes brain tumor invasion, SPARC was transfected into
U87MG glioblastoma cells using the tetracycline-off gene expression system. The parental
cell line (U87MG), the parental transactivator-transfected clone (U87T2) and three selected …
early in brain tumor progression. We identified and characterized SPARC (secreted protein
acidic and rich in cysteine) as a potential candidate. To determine whether increased
SPARC expression functionally promotes brain tumor invasion, SPARC was transfected into
U87MG glioblastoma cells using the tetracycline-off gene expression system. The parental
cell line (U87MG), the parental transactivator-transfected clone (U87T2) and three selected …