[HTML][HTML] Transforming growth factor-β-inducible phosphorylation of Smad3
G Wang, I Matsuura, D He, F Liu - Journal of Biological Chemistry, 2009 - ASBMB
Smad proteins transduce the transforming growth factor-β (TGF-β) signal at the cell surface
into gene regulation in the nucleus. Upon TGF-β treatment, the highly homologous Smad2
and Smad3 are phosphorylated by the TGF-β receptor at the SSXS motif in the C-terminal
tail. Here we show that in addition to the C-tail, three (S/T)-P sites in the Smad3 linker region,
Ser 208, Ser 204, and Thr 179 are phosphorylated in response to TGF-β. The linker
phosphorylation peaks at 1 h after TGF-β treatment, behind the peak of the C-tail …
into gene regulation in the nucleus. Upon TGF-β treatment, the highly homologous Smad2
and Smad3 are phosphorylated by the TGF-β receptor at the SSXS motif in the C-terminal
tail. Here we show that in addition to the C-tail, three (S/T)-P sites in the Smad3 linker region,
Ser 208, Ser 204, and Thr 179 are phosphorylated in response to TGF-β. The linker
phosphorylation peaks at 1 h after TGF-β treatment, behind the peak of the C-tail …