[HTML][HTML] Autoantibodies specific for the phospholipase A2 receptor in recurrent and de novo membranous nephropathy
H Debiec, L Martin, C Jouanneau, G Dautin… - American Journal of …, 2011 - Elsevier
Recent findings in idiopathic membranous nephropathy (MN) suggest that in most patients,
the disease is because of anti-phospholipase A 2 receptor (PLA 2 R1) autoantibodies. Our
aim was to analyze the prevalence and significance of anti-PLA 2 R1 antibodies in recurrent
and de novo MN after transplantation. We assessed circulating PLA 2 R1 autoantibodies by
a direct immunofluorescence assay based on human embryonic kidney cells transfected
with a PLA 2 R1 cDNA, and the presence of PLA 2 R1 antigen in immune deposits. We …
the disease is because of anti-phospholipase A 2 receptor (PLA 2 R1) autoantibodies. Our
aim was to analyze the prevalence and significance of anti-PLA 2 R1 antibodies in recurrent
and de novo MN after transplantation. We assessed circulating PLA 2 R1 autoantibodies by
a direct immunofluorescence assay based on human embryonic kidney cells transfected
with a PLA 2 R1 cDNA, and the presence of PLA 2 R1 antigen in immune deposits. We …
