[HTML][HTML] The lectin domain of the polypeptide GalNAc transferase family of glycosyltransferases (ppGalNAc Ts) acts as a switch directing glycopeptide substrate …
Mucin type O-glycosylation is initiated by a large family of polypeptide GalNAc transferases
(ppGalNAc Ts) that add α-GalNAc to the Ser and Thr residues of peptides. Of the 20 human
isoforms, all but one are composed of two globular domains linked by a short flexible linker:
a catalytic domain and a ricin-like lectin carbohydrate binding domain. Presently, the roles of
the catalytic and lectin domains in peptide and glycopeptide recognition and specificity
remain unclear. To systematically study the role of the lectin domain in ppGalNAc T …
(ppGalNAc Ts) that add α-GalNAc to the Ser and Thr residues of peptides. Of the 20 human
isoforms, all but one are composed of two globular domains linked by a short flexible linker:
a catalytic domain and a ricin-like lectin carbohydrate binding domain. Presently, the roles of
the catalytic and lectin domains in peptide and glycopeptide recognition and specificity
remain unclear. To systematically study the role of the lectin domain in ppGalNAc T …
