This brief overview sketches current evidence of imbalance between inducible nitric oxide
synthase (iNOS) and endothelial nitric oxide synthase (eNOS), role of oxidant stress, and
generation of peroxynitrite in the pathophysiology of acute ischemic renal injury. The
development of endothelial cell dysfunction at early stages of experimental acute renal
ischemia is the focus of the review, with the results of recent studies on amelioration of renal
injury by the infused endothelial cells engrafting in the renal microcirculation. Finally, this …