Disruption of Myosin 1e promotes podocyte injury

M Krendel, SV Kim, T Willinger, T Wang… - Journal of the …, 2009 - journals.lww.com
Abstract Myosin 1e (Myo1e) is one of two Src homology 3 domain–containing “long-tailed”
type I myosins in vertebrates, whose functions in health and disease are incompletely
understood. Here, we demonstrate that Myo1e localizes to podocytes in the kidney. We
generated Myo1e-knockout mice and found that they exhibit proteinuria, signs of chronic
renal injury, and kidney inflammation. At the ultrastructural level, renal tissue from Myo1e-
null mice demonstrates changes characteristic of glomerular disease, including a thickened …