Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis
F Marchesi, L Piemonti, A Mantovani… - Cytokine & growth factor …, 2010 - Elsevier
Invasion and metastasis are key components of cancer progression. Inflammatory
mediators, including cytokines and chemokines, can facilitate tumor dissemination. A distinct
and largely forgotten path is perineural invasion (PNI), defined as the presence of cancer
cells in the perinerium space. PNI is frequently used by many human carcinomas, in
particular by pancreas and prostate cancer, and is associated with tumor recurrence and
pain in advanced patients. Neurotrophic factors have been identified as molecular …
mediators, including cytokines and chemokines, can facilitate tumor dissemination. A distinct
and largely forgotten path is perineural invasion (PNI), defined as the presence of cancer
cells in the perinerium space. PNI is frequently used by many human carcinomas, in
particular by pancreas and prostate cancer, and is associated with tumor recurrence and
pain in advanced patients. Neurotrophic factors have been identified as molecular …