States of low perfusion pressure of the kidney associate with hyperplasia or expansion of
renin-producing cells, but it is unknown whether hypoxia-triggered genes contribute to these
changes. Here, we stabilized hypoxia-inducible transcription factors (HIFs) in mice by
conditionally deleting their negative regulator, Vhl, using the Cre/loxP system with renin-1d
promoter-driven Cre expression. Vhl−/− REN mice were viable and had normal BP. Deletion
of Vhl resulted in constitutive accumulation of HIF-2α in afferent arterioles and glomerular …